What does this research mean for the field?

The highly bioavailable amorphous curcumin formulation CurcuRouge® exhibits a favorable safety profile with no evidence of subacute toxicity and a no-observed-adverse-effect level (NOAEL) of 750 mg/kg/day in rats. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the subacute oral toxicity and determine the no-observed-adverse-effect level of the bioavailable curcumin formulation CurcuRouge® in rats over 28 days.

August 30, 2026Toxicology ReportsOpen Access

Evaluation of subacute toxicity of highly bioavailable curcuRouge® formulation by a repeated dose 28-day oral exposure toxicology study in sprague dawley rats with safety assessment

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Authors

MKMahendra P. KapoorKanagawa Academy of Science and Technology KMKaori MusumiTaisei (Japan)YKYasuhiro KatsuuraDebiopharm (Switzerland)

Discussion

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Implication

Repeated-dose toxicity study demonstrates high tolerability of CurcuRouge in Sprague Dawley rats, indicating a favorable safety margin for human exposure.

Key Points

To evaluate the subacute oral toxicity and determine the no-observed-adverse-effect level of the bioavailable curcumin formulation CurcuRouge® in rats over 28 days.
Orally administered CurcuRouge® at 750 mg/kg/day (equivalent to 300 mg/kg/day curcumin) to male and female Sprague–Dawley (Slc) rats for 28 consecutive days.
Monitored clinical signs, body weight, urinalysis, hematological and biochemical parameters, and performed postmortem gross pathological examinations.
No mortality, treatment-related clinical signs, or gross pathological abnormalities occurred, and body weights remained comparable between treated and control groups.
Serum albumin concentrations and albumin/globulin ratios increased significantly in both sexes without associated histopathological lesions, while observed cecal dilatation reflected an adaptive physiological response.
The no-observed-adverse-effect level (NOAEL) was established at 750 mg/kg/day, providing a safety margin greater than 16-fold.

Cite This Study

Kapoor et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0696c1a8fb52e79c8d4 https://doi.org/10.1016/j.toxrep.2026.102336

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Implication

Repeated-dose toxicity study demonstrates high tolerability of CurcuRouge in Sprague Dawley rats, indicating a favorable safety margin for human exposure.

Evaluation of subacute toxicity of highly bioavailable curcuRouge® formulation by a repeated dose 28-day oral exposure toxicology study in sprague dawley rats with safety assessment

Discussion

Member takes

Implication

Key Points

Cite This Study

Evaluation of subacute toxicity of highly bioavailable curcuRouge® formulation by a repeated dose 28-day oral exposure toxicology study in sprague dawley rats with safety assessment

Discussion

Member takes

Implication

Key Points

Cite This Study

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