What question did this study set out to answer?

To determine the magnitude and profile of impairment across different cognitive domains in individuals during the preclinical phase of Alzheimer's disease.

January 1, 2005Neuropsychology

Cognitive impairment in preclinical Alzheimer's disease: A meta-analysis.

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Authors

LBLars Bäckman SJSari Jones ABAnna‐Karin Berger

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Overview

Meta-analysis reveals marked multi-domain cognitive deficits in preclinical Alzheimer's disease, indicating widespread neurological impairment emerges years prior to clinical diagnosis.

Key Points

To determine the magnitude and profile of impairment across different cognitive domains in individuals during the preclinical phase of Alzheimer's disease.
Meta-analysis synthesizing 47 studies encompassing 1,207 preclinical Alzheimer's disease cases and 9,097 control participants.
Evaluated performance across cognitive domains—including global cognitive ability, episodic memory, executive functioning, perceptual speed, and verbal skills—stratified by age, follow-up interval, and testing method.
Marked preclinical deficits occurred in global cognitive ability, episodic memory, perceptual speed, and executive functioning, alongside moderate deficits in verbal ability, visuospatial skill, and attention, whereas primary memory remained intact.
Larger effect sizes for global cognitive ability and episodic memory were observed in cohorts younger than 75 years and with follow-up intervals under 3 years.
Delayed testing and recall-based assessment generated the largest effect sizes within the episodic memory domain.

Cite This Study

Bäckman et al. (2005) studied this question.

synapsesocial.com/papers/69ff89ecda5c1eb07f2d7c27 https://doi.org/10.1037/0894-4105.19.4.520

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January 1, 2005Neuropsychology

Cognitive impairment in preclinical Alzheimer's disease: A meta-analysis.

View Full Paper

Ask AI

Bookmark

Authors

LBLars Bäckman SJSari Jones ABAnna‐Karin Berger

Discussion

Member takes

Overview

Meta-analysis reveals marked multi-domain cognitive deficits in preclinical Alzheimer's disease, indicating widespread neurological impairment emerges years prior to clinical diagnosis.

Key Points

To determine the magnitude and profile of impairment across different cognitive domains in individuals during the preclinical phase of Alzheimer's disease.
Meta-analysis synthesizing 47 studies encompassing 1,207 preclinical Alzheimer's disease cases and 9,097 control participants.
Evaluated performance across cognitive domains—including global cognitive ability, episodic memory, executive functioning, perceptual speed, and verbal skills—stratified by age, follow-up interval, and testing method.
Marked preclinical deficits occurred in global cognitive ability, episodic memory, perceptual speed, and executive functioning, alongside moderate deficits in verbal ability, visuospatial skill, and attention, whereas primary memory remained intact.
Larger effect sizes for global cognitive ability and episodic memory were observed in cohorts younger than 75 years and with follow-up intervals under 3 years.
Delayed testing and recall-based assessment generated the largest effect sizes within the episodic memory domain.

Cite This Study

Bäckman et al. (2005) studied this question.

synapsesocial.com/papers/69ff89ecda5c1eb07f2d7c27 https://doi.org/10.1037/0894-4105.19.4.520

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