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Systematic review and meta-analysis shows higher blood pressure is linked to greater white matter lesions and brain atrophy in cognitively healthy adults, indicating worse overall cerebral health.
BACKGROUND: To summarise and quantify the evidence on the association between Blood pressure (BP), white matter lesions (WMLs), and brain volumes. METHOD: Electronic databases PubMed, Scopus, and Clarivate were searched in February 2020 using an established methodology and pre-determined search terms. Studies were eligible for inclusion if they reported on the association between BP and WMLs or brain volume in cognitively healthy individuals, while adjusting for age and intra-cranial volume. CONCLUSION: The association between BP and brain volumes appears across the full range of BP measurements and is not limited to hypertensive individuals. Higher BP in community-residing individuals is associated with poorer cerebral health.
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Alateeq et al. (2021) studied this question.
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