Why the study?
Are lower blood pressure parameters associated with reduced cortical and subcortical brain volumes in older persons with mild cognitive deficits?
Population
220 older persons with mild cognitive deficits using antihypertensive medication, mean age 80.7, 43% men…
Design
Cross-sectional
Key result
Lower systolic and diastolic blood pressure and mean arterial pressure were significantly associated with reduced volumes of the thalamus and putamen (all P≤0.01) and hippocampus (P=0.035).
Authors
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May warrant caution with intensive BP lowering in elderly with mild deficits; leaves open causality, needing longitudinal confirmation.
Cross-Sectional (n=220)
Are lower blood pressure parameters associated with reduced cortical and subcortical brain volumes in older persons with mild cognitive deficits?
p-value: p=≤ 0.01
In older persons with mild cognitive deficits on antihypertensive therapy, lower blood pressure is associated with reduced subcortical brain volumes, suggesting potential risks of aggressive blood pressure lowering in this population.
Foster‐Dingley et al. (2015) conducted a cross-sectional in Mild cognitive deficits (n=220). Blood pressure was evaluated on Cortical and subcortical brain volumes (p=≤ 0.01). Lower systolic and diastolic blood pressure and mean arterial pressure were significantly associated with reduced volumes of the thalamus and putamen (all P≤0.01) and hippocampus (P=0.035).
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