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December 24, 2017Open Access

Lower regional grey matter volume was correlated with higher peripheral blood pressure, including in sub-hypertensive categories compared to optimal blood pressure.

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Why the study?

Is elevated blood pressure associated with lower grey matter volume in healthy young adults?

Population

423 healthy adults between 19-40 years without prior diagnosis of hypertension, from four cross-sectional…

Comparison

Elevated resting blood pressure <120/<80, 2)… vs Optimal blood pressure (SBP <120 and DBP <80 mmHg)

Design

Cross-sectional

Authors

HSH. Lina SchaareSMShahrzad Kharabian MasoulehFBFrauke Beyer

Discussion

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Overview

BP effects on grey matter may emerge early and below thresholds in young adults; extends prior associations but leaves open causality and prevention.

Structured PICO

Is elevated blood pressure associated with lower grey matter volume in healthy young adults?

P
Population
423 healthy adults between 19-40 years (mean age=27.7±5.3 years, 177 women) without prior diagnosis of hypertension, from four cross-sectional studies in Leipzig, Germany.
I
Intervention
Elevated resting blood pressure (categorized into 4 groups: 1) <120/<80, 2) 120-129/80-84, 3) 130-139/85-89, 4) ≥140/≥90 mmHg)
C
Comparator
Optimal blood pressure (SBP <120 and DBP <80 mmHg)
O
Outcome
Grey matter volume (GMV) measured by structural 3 Tesla T1-weighted MRIsurrogate

Blood pressure-associated grey matter alterations emerge continuously across the BP range in early adulthood, suggesting early BP control may be important for preventing asymptomatic cerebrovascular disease.

Cite This Study

Schaare et al. (2017) studied this question.

synapsesocial.com/papers/6a7c3194d51985d5a1c29db0https://doi.org/10.1101/239160
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