Why the study?
Are diastolic and systolic blood pressure components associated with MRI biomarkers of dementia-related brain pathology in older adults?
Population
227 members of the Aberdeen 1936 Birth Cohort between ages 64 and 68 years.
Design
Cohort
Follow-up
4 years (between ages 64 and 68 years)
Key result
Higher diastolic blood pressure predicted increased white matter hyperintensities (β=0.13, P=0.044) and smaller hippocampi (β=-0.25, P=0.006) in older adults.
Authors
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Suggests diastolic BP control may mitigate structural brain aging; leaves open whether targeted diastolic.
Cohort (n=227)
Are diastolic and systolic blood pressure components associated with MRI biomarkers of dementia-related brain pathology in older adults?
Effect estimate: β = 0.13 for WMH; β = -0.25 for hippocampal volume
p-value: p=0.044 for WMH; 0.006 for hippocampal volume
Increased diastolic blood pressure is associated with MRI biomarkers of cerebrovascular and Alzheimer's diseases, highlighting the importance of individual BP components in brain aging.
McNeil et al. (2017) conducted a cohort in Brain ageing (n=227). Diastolic and systolic blood pressure and their visit-to-visit variability was evaluated on White matter hyperintensity (WMH) abundance and hippocampal volume (β = 0.13 for WMH; β = -0.25 for hippocampal volume, p=0.044 for WMH; 0.006 for hippocampal volume). Higher diastolic blood pressure predicted increased white matter hyperintensities (β=0.13, P=0.044) and smaller hippocampi (β=-0.25, P=0.006) in older adults.