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October 22, 2009American Journal of HypertensionOpen Access

Blood Pressure, Aging, Vascular Disease, and Their Effects on Brain Volume

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Why the study?

Does blood pressure influence the progression of brain atrophy in patients with vascular disease?

Population

331 patients with heterogeneous vascular diseases, mean age 58 years

Design

Editorial

Follow-up

mean 4.1 years

Key result

Blood pressure did not significantly influence the rate of change in brain tissue volume over a mean follow-up of 4.1 years in 331 patients with vascular disease.

Authors

MNMichiaki NagaiKKKazuomi Kario

Discussion

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Member takes

Overview

BP control may not slow brain atrophy in vascular disease; leaves open confounding by age, baseline BP, and cardiac function.

Structured PICO

Does blood pressure influence the progression of brain atrophy in patients with vascular disease?

P
Population
331 patients with vascular disease, mean age 58 years and mean clinic BP 138/80 mm Hg, followed for a mean of 4.1 years.
E
Exposure
Blood pressure levels (observational exposure)
O
Outcome
Progression of brain atrophy (rate of change in brain tissue volume)surrogate

This editorial highlights that while a recent study found no association between blood pressure and brain atrophy progression in a relatively young cohort with vascular disease, factors like age, baseline BP, and cardiac function may confound this relationship.

Limitations

  • Patients were younger and had lower BP levels than patients in similar studies.
  • Subjects with heterogeneous vascular diseases were included, making it problematic to compare with earlier studies.
  • Insufficient information regarding cardiac function, which might confound the relationship.
  • A single clinic BP measure might not be sufficient to detect a significant BP impact compared to ambulatory or nocturnal BP.
  • Younger patients with lower BP levels than previous studies
  • Heterogeneous vascular diseases included
  • Insufficient information regarding cardiac function
  • Single clinic BP measure used instead of ambulatory BP monitoring

Cite This Study

Nagai et al. (2009) conducted an editorial in vascular disease (n=331). Blood pressure was evaluated on rate of change in brain tissue volume. Blood pressure did not significantly influence the rate of change in brain tissue volume over a mean follow-up of 4.1 years in 331 patients with vascular disease.

synapsesocial.com/papers/6aa261d992dfe0a384a72c7ehttps://doi.org/10.1038/ajh.2009.179
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ambulatory blood pressure and brain atrophy in the healthy elderly2002 · 67 citations
  2. 2Association Between Ambulatory 24-Hour Blood Pressure Levels and Brain Volume Reduction2012 · 31 citations
  3. 3Ambulatory blood pressure and the brain2005 · 108 citations
  4. 4Blood Pressure and Brain Injury in Older Adults: Findings from a Community‐Based Autopsy Study2009 · 67 citations
  5. 5ASSOCIATION OF AMBULATORY BLOOD PRESSURE VARIABILITY WITH BRAIN ATROPHY IN HYPERTENSIVE PATIENTS2026