Why the study?
Do initial values of casual and ambulatory systolic blood pressure predict white matter hyperintensities and brain atrophy 5 years later in healthy elderly individuals?
Population
155 healthy men and women, aged 55 to 79 years, with relatively low initial average casual blood pressure.
Design
Cohort
Follow-up
5 years
Key result
Small increases in casual and 24-hour ambulatory BP from a relatively low baseline (116.9/71.1 mm Hg) were associated with greater brain atrophy and subcortical lesions after 5 years.
Authors
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Supports BP surveillance even at low baselines in elderly; leaves open whether lowering prevents atrophy.
Cohort (n=155)
Do initial values of casual and ambulatory systolic blood pressure predict white matter hyperintensities and brain atrophy 5 years later in healthy elderly individuals?
Even in healthy elderly individuals with relatively low baseline blood pressure, small increases in casual and ambulatory systolic blood pressure predict greater brain atrophy and subcortical lesions over 5 years.
Goldstein et al. (2005) conducted a cohort in Healthy elderly individuals (n=155). Casual and ambulatory systolic blood pressure was evaluated on White matter hyperintensities, insular subcortex hyperintensities, and brain atrophy. Small increases in casual and 24-hour ambulatory BP from a relatively low baseline (116.9/71.1 mm Hg) were associated with greater brain atrophy and subcortical lesions after 5 years.
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