Why the study?
Does higher ambulatory blood pressure and its variability associate with brain atrophy in healthy elderly individuals?
Population
155 healthy men and women, divided into younger (56 to 66 years old) and older (67 to 80 years old) subgroups
Comparison
Ambulatory blood pressure vs Lower blood pressure levels and lower blood…
Design
Cross-sectional
Key result
Higher ambulatory blood pressure levels and greater BP variability within the upper normal range were associated with smaller brain volumes and larger ventricles in healthy elderly individuals.
Authors
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Should not yet change BP targets in healthy elderly; hypothesis-generating for ambulatory monitoring and brain atrophy.
Cross-Sectional (n=155)
Does higher ambulatory blood pressure and its variability associate with brain atrophy in healthy elderly individuals?
Even in healthy individuals without diagnosed hypertension, higher blood pressure levels within the upper normal range and greater BP variability are associated with increased brain atrophy.
Goldstein et al. (2002) conducted a cross-sectional in Healthy elderly individuals (n=155). Ambulatory blood pressure was evaluated on MRI volume measurements of total brain and lateral and third ventricles. Higher ambulatory blood pressure levels and greater BP variability within the upper normal range were associated with smaller brain volumes and larger ventricles in healthy elderly individuals.
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