Why the study?
Are ambulatory 24-hour blood pressure levels associated with focal brain volume reduction and executive function decline in adults?
Population
183 participants, mean age 65 ± 0.6 years, 62.4% women
Design
Cross-sectional
Key result
Higher 24-hour ambulatory blood pressure was significantly associated with decreased gray matter volume in frontal areas, which correlated with a decline in executive function performance.
Authors
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May link ambulatory hypertension to frontal atrophy and executive decline; hypothesis-generating, should not yet change practice.
Cross-Sectional (n=183)
Are ambulatory 24-hour blood pressure levels associated with focal brain volume reduction and executive function decline in adults?
High ambulatory blood pressure is associated with focal gray matter volume reduction, which correlates with executive function decline, suggesting a structural mechanism for hypertension-related cognitive impairment.
Celle et al. (2012) conducted a cross-sectional in High blood pressure (n=183). 24-hour ambulatory blood pressure was evaluated on Cortical gray and white matter volumes and executive function performance. Higher 24-hour ambulatory blood pressure was significantly associated with decreased gray matter volume in frontal areas, which correlated with a decline in executive function performance.