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September 28, 2009Journal of the American Geriatrics SocietyOpen Access

In participants aged 65-80, the relative risk for more than two microinfarcts with each 10-mmHg increase in SBP was 1.15 (95% CI 1.00-1.33), and was particularly strong in those not taking antihypertensive medications (RR 1.48, 95% CI 1.21-1.81).

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Why the study?

Does higher blood pressure correlate with dementia-related pathological brain changes in cognitively normal older adults?

Population

250 participants aged 65 and older, cognitively normal at time of enrollment in the Adult Changes in Thought…

Design

Cohort

Authors

LWLucy Y. WangELEric B. LarsonJSJoshua A. Sonnen

Discussion

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Overview

Observational SBP-microinfarct link in untreated older adults; leaves open whether BP lowering alters dementia pathology.

Structured PICO

Does higher blood pressure correlate with dementia-related pathological brain changes in cognitively normal older adults?

P
Population
250 participants aged 65 and older, cognitively normal at time of enrollment in the Adult Changes in Thought (ACT) Study, who underwent autopsy. Based in a large health maintenance organization in Seattle, Washington.
I
Intervention
Systolic and diastolic blood pressure levels at enrollment (observational)
O
Outcome
Pathological changes in the cerebrum (cystic macroscopic infarcts, microinfarcts, neuritic plaques, neurofibrillary tangles, and cortical Lewy bodies) assessed at autopsysurrogate

Higher systolic blood pressure is associated with an increased risk of cerebral microinfarcts in older adults aged 65-80, particularly those not receiving antihypertensive treatment.

Cite This Study

Wang et al. (2009) studied this question.

synapsesocial.com/papers/6a1bf9570a1f7575939d496ahttps://doi.org/10.1111/j.1532-5415.2009.02493.x
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