Why the study?
Is lower blood pressure associated with cerebral small vessel disease and loss of gray matter integrity in older persons?
Population
220 participants aged 75 years and older from the Discontinuation of Antihypertensive Treatment in the…
Design
Cohort
Key result
Lower systolic and diastolic blood pressure and mean arterial pressure were associated with worse gray matter integrity in 220 older participants aged ≥75 years.
Authors
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May warrant caution with low BP targets in adults ≥75; hypothesis-generating, needs prospective confirmation.
Observational (n=220)
Is lower blood pressure associated with cerebral small vessel disease and loss of gray matter integrity in older persons?
In older adults aged 75 and above, lower blood pressure is associated with worse gray matter integrity, suggesting that lower BP thresholds should be carefully considered in this population.
Foster‐Dingley et al. (2015) conducted an observational in Cerebral small vessel disease and gray matter integrity loss (n=220). Blood pressure was evaluated on Signs of cerebral small vessel disease (cSVD) and gray and white matter integrity. Lower systolic and diastolic blood pressure and mean arterial pressure were associated with worse gray matter integrity in 220 older participants aged ≥75 years.
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