Why the study?
Is hypertension associated with reduced brain volumes and increased white matter lesions in older subjects?
Population
154 subjects age >= 70 years, including 103 hypertensive and 51 normotensive individuals.
Comparison
Hypertension vs Normotension
Design
Cross-sectional
Authors
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Hypertension was associated with smaller brain volumes and more periventricular lesions in older adults; hypothesis-generating and needs longitudinal confirmation before practice change.
Is hypertension associated with reduced brain volumes and increased white matter lesions in older subjects?
Moderate hypertension in older adults is associated with smaller whole brain volume and increased subcortical and periventricular white matter lesions, suggesting a structural mechanism for hypertension-associated cognitive impairment.
Wiseman et al. (2004) studied this question.
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