What question did this study set out to answer?

To determine the prevalence of hypertension associated with an elevated aldosterone to renin ratio in a representative primary care population.

September 1, 2004The Journal of Clinical Endocrinology & MetabolismOpen Access

Aldosterone to Renin Ratio in a Primary Care Setting: The Bussolengo Study

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Why the study?

What is the prevalence of an elevated aldosterone to renin ratio among hypertensive patients in a primary care setting?

Key Points

To determine the prevalence of hypertension associated with an elevated aldosterone to renin ratio in a representative primary care population.
Randomly sampled 1,462 adults aged 35–74 years from a northern Italian health district registry, yielding 1,348 individuals with complete general practitioner evaluations.
Withdrew antihypertensive medications (except verapamil or alpha-blockers) for 4 weeks before collecting upright plasma direct active renin and aldosterone in 287 of 412 hypertensive patients (70% response rate).
An elevated aldosterone to active renin ratio (≥32 pg/ml, equivalent to 50 ng/dl per ng/ml·h) occurred in 32.4% of tested hypertensive individuals.
Elevated ratio prevalence was higher among female patients and individuals aged 55 years or older.

Structured PICO

What is the prevalence of an elevated aldosterone to renin ratio among hypertensive patients in a primary care setting?

Population

1,348 adults aged 35-74 years randomly selected from the population register of the Bussolengo Health District (northern Italy), including 412 identified hypertensive patients (287 of whom underwent blood testing).

Intervention

Measurement of direct active renin and aldosterone in plasma to calculate the aldosterone to active renin ratio (AARR).

Outcome

Prevalence of elevated aldosterone to active renin ratio (AARR ≥32 pg/ml).surrogate

An elevated aldosterone to active renin ratio is highly prevalent (32.4%) among general hypertensive patients in primary care, suggesting that screening for primary aldosteronism should not be restricted to specialist units.

Discussion

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Implication

May support broader PA screening in primary care hypertension; extends prevalence data but remains hypothesis-generating.

Cite This Study

Olivieri et al. (2004) studied this question.

synapsesocial.com/papers/69ffcb467e61d2a3f0c22f70 https://doi.org/10.1210/jc.2003-032179

Topics

Hypertension management

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Aldosterone to Renin Ratio in a Primary Care Setting: The Bussolengo Study

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Aldosterone to Renin Ratio in a Primary Care Setting: The Bussolengo Study

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider