Key result
Serial multiparametric CMR detects early doxorubicin cardiotoxicity at a reversible stage in preclinical models.
Why the study?
Anthracycline-induced cardiotoxicity is a major clinical problem, and early cardiotoxicity markers are needed.
Does serial multiparametric cardiac magnetic resonance (CMR) identify early doxorubicin-induced cardiotoxicity in a large animal model?
Does serial multiparametric cardiac magnetic resonance (CMR) identify early doxorubicin-induced cardiotoxicity in a large animal model?
Serial multiparametric CMR can identify anthracycline-induced cardiotoxicity at an early, reversible disease stage in a large animal model.
Answers are grounded in this paper and cite their sources.
Supports serial CMR for early reversible doxorubicin cardiotoxicity in large animals; leaves open human validation.
BACKGROUND: Anthracycline-induced cardiotoxicity is a major clinical problem, and early cardiotoxicity markers are needed. OBJECTIVES: The purpose of this study was to identify early doxorubicin-induced cardiotoxicity by serial multiparametric cardiac magnetic resonance (CMR) and its pathological correlates in a large animal model. METHODS: mapping (including extracellular volume [ECV] quantification). A control group was sacrificed after the initial CMR. RESULTS: prolongation occurs at a reversible disease stage. CONCLUSIONS: mapping, ECV, or LV motion defects. The occurrence of these changes at a reversible disease stage shows the clinical potential of this CMR marker for tailored anthracycline therapy.
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Galán‐Arriola et al. (2019) studied Anthracycline-induced cardiotoxicity. Serial multiparametric cardiac magnetic resonance (CMR) vs. Control group was evaluated on Early doxorubicin-induced cardiotoxicity markers. Serial multiparametric cardiac magnetic resonance identified early doxorubicin-induced cardiotoxicity changes at a reversible disease stage in a large animal model.
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