Why the study?
Do maternal hemodynamics and uterine artery Doppler at 24 weeks gestation differ between women who subsequently develop early versus late preeclampsia?
Population
1345 nulliparous normotensive asymptomatic women at 24 weeks gestation, of whom 107 subsequently developed…
Design
Cohort
Follow-up
Until development of preeclampsia or delivery
Authors
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Supports distinct hemodynamic profiles in early vs late preeclampsia; hypothesis-generating and requires prospective validation before clinical use.
Do maternal hemodynamics and uterine artery Doppler at 24 weeks gestation differ between women who subsequently develop early versus late preeclampsia?
Early and late preeclampsia appear to originate from different hemodynamic states, with early preeclampsia characterized by high vascular resistance and late preeclampsia associated with higher BMI and lower vascular resistance.
Valensise et al. (2008) studied this question.
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