August 5, 2015Stroke
Prognostic Significance of Short-Term Blood Pressure Variability in Acute Stroke
Why the study?
Does greater short-term blood pressure variability increase the risk of poor functional outcome in patients with acute stroke?
Population
Patients with acute stroke; meta-analysis including 18 studies.
Comparison
Greater short-term systolic blood pressure… vs Lower blood pressure variability.
Design
Meta-analysis
Follow-up
longer-term
Authors
Discussion
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Member takes
Implication
May inform acute stroke risk stratification; strengthens meta-analytic evidence linking systolic BPV to poor outcomes.
Structured PICO
Does greater short-term blood pressure variability increase the risk of poor functional outcome in patients with acute stroke?
P
Population
Patients with acute stroke (ischemic stroke or intracerebral hemorrhage); meta-analysis including 18 studies (7 studies in the quantitative meta-analysis).
I
Intervention
Greater short-term systolic blood pressure variability (BPV) measured early from stroke onset.
C
Comparator
Lower blood pressure variability (analyzed per 10-mm Hg increment).
O
Outcome
Poor functional outcome (death or disability).hard clinical
Greater short-term systolic blood pressure variability following acute stroke is significantly associated with worse long-term functional outcomes and potential increased risk of intracranial hemorrhage with thrombolysis.
Cite This Study
Manning et al. (2015) studied this question.