Key result
Short-term blood pressure variability derived from casual cuff measures was not significantly associated with 2-week death or disability after acute stroke (OR 0.98; 95% CI 0.78-1.23).
Why the study?
Does short-term blood pressure variability predict death and disability at 2 weeks in acute stroke patients?
Observational (n=877)
Does short-term blood pressure variability predict death and disability at 2 weeks in acute stroke patients?
Odds Ratio: 0.98 (95% CI 0.78–1.23)
p-value: p=Not significant
Short-term blood pressure variability derived from casual cuff measures does not predict early (2-week) death or disability after acute stroke.
Casual BPV measures should not guide early prognosis after acute stroke; leaves open whether continuous monitoring or longer-term variability improves prediction.
BACKGROUND AND PURPOSE: Short-term blood pressure variability (BPV) may predict outcome in acute stroke. We undertook a post hoc analysis of data from 2 randomized controlled trials to determine the effect of short-term BPV on 2-week outcome. METHODS: Controlling Hypertension and Hypotension Immediately Post Stroke (CHHIPS) was a trial of BP-lowering, enrolling 179 acute stroke patients (onset<36 hours). Continue or Stop Post-Stroke Antihypertensives Collaborative Study (COSSACS) compared a strategy of continuation versus temporarily stopping prestroke antihypertensive therapy in 763 acute stroke patients (onset<48 hours). BPV at baseline (defined as SD, coefficient of variation, variation independent of the mean, and average real variability) was derived from standardized casual cuff BP measures (6 readings<30 minutes). Adjusted logistic regression models were used to assess the relation between BPV and death and disability (modified Rankin scale>3) at 2 weeks. RESULTS: Seven hundred six (92.5%) and 171 (95.5%) participants were included in the analysis for the COSSACS and CHHIPS data sets, respectively. Adjusted logistic regression analyses revealed no statistically significant associations between any of the included BPV parameters with 2-week death or disability in either study data set: COSSACS, odds ratio SD systolic BP 0.98 (0.78-1.23); CHHIPS, odds ratio SD systolic BP 0.97 (0.90-1.11). CONCLUSIONS: When derived from casual cuff BP measures, short-term BPV is not a useful predictor of early (2 weeks) outcome after acute stroke. Differing methodology may account for the discordance with previous studies indicating long-term (casual BPV) and short-term (beat-to-beat BPV) prognostic value. CLINICAL TRIAL REGISTRATION: COSSACS was registered on the International Standard Randomised Controlled Trial Register; URL: http://www.isrctn.com. Unique identifier: ISRCTN89712435. CHHIPS was registered on the National Research Register; URL: http://public.ukcrn.org.uk. Unique identifier: N0484128008.
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Manning et al. (2015) conducted an observational in Acute stroke (n=877). Short-term blood pressure variability (BPV) was evaluated on Death and disability (modified Rankin scale >3) at 2 weeks (OR 0.98, 95% CI 0.78-1.23, p=Not significant). Short-term blood pressure variability derived from casual cuff measures was not significantly associated with 2-week death or disability after acute stroke (OR 0.98; 95% CI 0.78-1.23).
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