Key result
Antihypertensive adjustments that improve systolic BP variability are linked to better 90-day ischemic stroke outcomes.
Why the study?
High blood pressure variability in hypertension is linked to increased acute ischemic stroke risk and poor outcomes, so managing it may improve post-stroke prognosis.
Does antihypertensive regimen adjustment based on 24-h ABPM improve 90-day mRS and NIHSS scores in patients with acute ischemic stroke and hypertension?
Cohort (n=75)
Does antihypertensive regimen adjustment based on 24-h ABPM improve 90-day mRS and NIHSS scores in patients with acute ischemic stroke and hypertension?
p-value: p=<0.05
Tailored antihypertensive therapy to reduce blood pressure variability may improve 90-day functional outcomes in patients with acute ischemic stroke and hypertension.
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Hypothesis-generating for acute BPV reduction in hypertensive AIS; RCTs needed before clinical adoption.
Yan et al. (2026) conducted a cohort in Acute ischemic stroke and hypertension (n=75). Antihypertensive regimen adjustments based on 24-h ambulatory blood pressure monitoring vs. Control group (systolic blood pressure variability 10-20%) was evaluated on Modified Rankin Scale (mRS) and National Institutes of Health Stroke Scale (NIHSS) scores at 90 days (p=<0.05). Patients with acute ischemic stroke and abnormal systolic blood pressure variability who achieved improved variability after antihypertensive adjustment had better 90-day outcomes (p < 0.05).