Key result
Increased blood pressure variability (standard deviation) during the subacute phase of severe stroke was associated with poor 90-day outcomes (OR 1.10; 95% CI 1.03-1.17; p=0.007).
Why the study?
The influence of blood pressure variability on outcomes in patients with severe stroke remains largely unsettled.
Does increased blood pressure variability correlate with poor outcomes (90-day mRS ≥ 3) in patients with acute severe stroke?
Population
Patients with severe stroke (442 in acute phase, 390 in subacute phase)
Comparison
Blood pressure variability measurements and systolic blood pressure standard deviation quintiles
Design
Post hoc analysis of a randomized controlled trial
Follow-up
90 days
Authors
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Higher subacute BPV was associated with poor 90-day outcomes in severe stroke; extends evidence for variability as a potential target.
Cohort (n=442)
Does increased blood pressure variability correlate with poor outcomes (90-day mRS ≥ 3) in patients with acute severe stroke?
Odds Ratio: 1.1 (95% CI 1.03–1.17)
p-value: p=0.007
Increased blood pressure variability during the subacute phase of severe stroke is strongly associated with poor functional outcomes at 90 days.
Zhao et al. (2020) conducted a cohort in acute severe stroke (n=442). Blood pressure variability (BPV) vs. Lower blood pressure variability was evaluated on 90-day modified Rankin scale (mRS) ≥ 3 (OR 1.10, 95% CI 1.03-1.17, p=0.007). Increased blood pressure variability (standard deviation) during the subacute phase of severe stroke was associated with poor 90-day outcomes (OR 1.10; 95% CI 1.03-1.17; p=0.007).
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