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April 12, 2000JAMA

Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community-Based Study

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Authors

FNF. Javier NietoAlexander von Humboldt Biological Resources Research Institute

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Implication

Cross-sectional study finds an independent association between sleep-disordered breathing and hypertension in middle-aged and older adults, suggesting sleep apnea elevates cardiovascular risk.

Key Points

  • To evaluate the association between sleep-disordered breathing (SDB) and hypertension in a large community-based cohort of middle-aged and older individuals.
  • Conducted cross-sectional analyses of 6,132 participants (aged ≥40 years; 52.8% female) from the multicenter Sleep Heart Health Study between 1995 and 1998.
  • Quantified SDB using unattended home polysomnography to measure the apnea-hypopnea index (AHI) and the percentage of sleep time below 90% oxyhemoglobin saturation.
  • Assessed hypertension (resting blood pressure ≥140/90 mm Hg or antihypertensive medication use) adjusting for demographics, BMI, waist-to-hip ratio, neck circumference, alcohol intake, and smoking.
  • The adjusted odds ratio (OR) for hypertension comparing the highest AHI category (≥30/hour) to the lowest (<1.5/hour) was 1.37 (95% CI, 1.03–1.83; P for trend = .005).
  • Participants with ≥12% of sleep time below 90% oxygen saturation had higher odds of hypertension compared to those with <0.05% (adjusted OR 1.46; 95% CI, 1.12–1.88; P for trend <.001).
  • Significant associations persisted across both sexes, all age and ethnic groups, and normal-weight and overweight individuals, whereas arousal index and self-reported snoring showed nonsignificant links.

Cite This Study

F. Javier Nieto (2000) studied this question.

synapsesocial.com/papers/69ffce8d6018b8d0892d986fhttps://doi.org/10.1001/jama.283.14.1829
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Undiagnosed Sleep Apnea in Patients with Essential Hypertension1985 · 452 citations
  2. 2Hypopnea, a Floating Metric: Implications for Prevalence, Morbidity Estimates, and Case Finding1997 · 85 citations
  3. 3Predictors and prevalence of obstructive sleep apnoea and snoring in 1001 middle aged men.1991 · 642 citations
  4. 4Causes and Consequences of Blood Pressure Alterations in Obstructive Sleep Apnea1991 · 80 citations
  5. 5Estimating Relative Risk Functions in Case-Control Studies Using a Nonparametric Logistic Regression1996 · 23 citations