Why the study?
Does targeted disruption of the ApoC-III gene reduce triglyceride levels and postprandial hypertriglyceridemia in mice?
Population
Mice (generated via gene targeting in embryonic stem cells)
Comparison
Targeted disruption of the apolipoprotein C-III… vs Wild type control mice
Design
Preclinical
Authors
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Hypothesis-generating for ApoC-III inhibition; human trials needed before clinical consideration.
Does targeted disruption of the ApoC-III gene reduce triglyceride levels and postprandial hypertriglyceridemia in mice?
Targeted disruption of the ApoC-III gene in mice reduces fasting triglycerides and abolishes postprandial hypertriglyceridemia, indicating its role in triglyceride-rich lipoprotein catabolism.
Maeda et al. (1994) studied this question.
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