Why the study?
Do AT1 receptor-agonistic antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization compared to normotensive pregnant patients?
Population
Sera of 30 pregnant patients (16 diagnosed with severe preeclampsia and 14 normotensive)
Comparison
IgG from preeclamptic patients vs IgG from normotensive pregnant patients
Design
Case-control
Authors
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AT1-agonistic IgG may contribute to preeclampsia calcium dysregulation; leaves open causal role and therapeutic targeting.
Do AT1 receptor-agonistic antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization compared to normotensive pregnant patients?
Maternal antibodies capable of activating AT1 receptors likely account for increased intracellular free Ca2+ concentrations and changes in gene expression associated with preeclampsia.
Thway et al. (2004) studied this question.
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