What question did this study set out to answer?

To evaluate the association between depression and the risk of metabolic syndrome through a systematic review and meta-analysis of observational studies.

March 2, 2021Clinical Diabetes and EndocrinologyOpen Access

The relationship between depression and risk of metabolic syndrome: a meta‐analysis of observational studies

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Why the study?

The relationship between metabolic syndrome and depression has been controversial, with different studies reporting conflicting results.

Is depression associated with an increased risk of metabolic syndrome?

Population

399,494 individuals across 49 studies

Comparison

Depressed vs non-depressed individuals

Design

Meta-analysis of cohort and cross-sectional studies

Authors

YMYousef MoradiUniversity of Massachusetts Lowell AAAhmed N. AlbatinehLehigh University HMHassan MahmoodiKurdistan University of Medical Sciences

Discussion

Member takes

Implication

Suggests considering metabolic screening in depression; confirms association yet leaves causality and intervention effects open.

Key Points

To evaluate the association between depression and the risk of metabolic syndrome through a systematic review and meta-analysis of observational studies.
Systematic search of PubMed, Scopus, Embase, and ISI databases from January 1990 to February 2020 for cohort and cross-sectional studies.
Methodological quality evaluated via the Newcastle-Ottawa Scale, including subgroup analyses and meta-regression across 49 studies (N=399,494).
Depressed individuals had significantly higher odds of metabolic syndrome compared to non-depressed controls across study designs (OR: 1.48; 95% CI: 1.33–1.64 vs. OR: 1.38; 95% CI: 1.17–1.64).
Cross-sectional studies demonstrated that depressed women experienced substantially higher odds of metabolic syndrome (OR: 1.95; 95% CI: 1.38–2.74) compared to men.
Geographic variations showed higher odds in Europe for cross-sectional studies (OR: 1.35; 95% CI: 1.47–1.99) and America for cohort studies (OR: 1.46; 95% CI: 1.16–1.84), with odds decreasing as age increased.

Structured PICO

Is depression associated with an increased risk of metabolic syndrome?

Population

399,494 individuals from 49 observational (cohort and cross-sectional) studies

Intervention

Depression

Comparator

No depression

Outcome

Metabolic syndrome (MetS)

Depression is significantly associated with an increased risk of metabolic syndrome, highlighting the importance of metabolic screening in depressed patients.

Cite This Study

Moradi et al. (2021) studied this question.

synapsesocial.com/papers/69fff609948103423c851deb https://doi.org/10.1186/s40842-021-00117-8

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The relationship between depression and risk of metabolic syndrome: a meta‐analysis of observational studies

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The relationship between depression and risk of metabolic syndrome: a meta‐analysis of observational studies

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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