Why the study?
Does aspirin reduce the composite of major stroke, myocardial infarction, or vascular death in patients with a transient ischaemic attack or minor ischaemic stroke?
Population
2,435 patients with a transient ischaemic attack or minor ischaemic stroke
Comparison
Aspirin 600 mg twice daily or aspirin 300 mg… vs Placebo (n=814)
Design
RCT, randomly allocated, blind
Follow-up
until September 30, 1986 (enrolled 1979-1985)
Authors
Loading...
Aspirin yields a non-significant reduction in major vascular events after TIA or minor stroke; leaves open its net benefit and optimal regimen.
Does aspirin reduce the composite of major stroke, myocardial infarction, or vascular death in patients with a transient ischaemic attack or minor ischaemic stroke?
In patients with TIA or minor ischemic stroke, aspirin therapy resulted in a non-statistically significant 15% reduction in the odds of major vascular events compared to placebo, with the 300 mg daily dose being less gastrotoxic than the 1200 mg daily dose.
Farrell et al. (1991) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: