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May 6, 2026International Journal of Molecular Medicine

Advances in understanding the NLRP3 inflammasome‑mediated mechanisms and therapeutic targets in diabetic nephropathy (Review)

Xiwei Wang Shuang Li Xiaotian Ge Tao Xie Sainan Li Ruiqi Yuan Tianxi Li Hui Yuan

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Key Points

This review aims to elucidate the mechanisms of the NLRP3 inflammasome in diabetic nephropathy and explore potential therapeutic targets.
Reviewed current research on the role of the NLRP3 inflammasome in diabetic nephropathy.
Evaluated small-molecule inhibitors, traditional Chinese medicine compounds, and gene therapy as therapeutic approaches.
Provided a roadmap for clinical translation based on validated findings.
Identified significant insights into the pathogenesis of diabetic nephropathy linked to NLRP3 inflammasome activity.
Outlined potential therapeutic targets including small-molecule inhibitors and herbal compounds.
Recommended directions for future experimental studies on NLRP3 inflammasome mechanisms.

Implication

Review highlights NLRP3 inflammasome mechanisms in diabetic nephropathy, suggesting new therapeutic avenues.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a001ff2c8f74e3340f9b229 https://doi.org/10.3892/ijmm.2026.5847

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