Discovery of Lignans and Stilbenes from the Seeds of Astragalus complanatus in Ferroptosis Regulation via Directly Acting on SLC7A11/GPX4 Pathway

K Zhao; Xu-Tong Fang; Shi-Qin Wang; Yue-Tong Zhu; Yong-Kuang Pan; Qiang‐Qiang Shi; Yu-Qi Gao; Jin-Ming Gao

doi:10.1021/acs.jafc.6c00397

May 7, 2026Journal of Agricultural and Food Chemistry

Discovery of Lignans and Stilbenes from the Seeds of Astragalus complanatus in Ferroptosis Regulation via Directly Acting on SLC7A11/GPX4 Pathway

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Key Points

The study aims to discover lignans and stilbenes from Astragalus complanatus and their role in regulating ferroptosis.
Utilized network pharmacology to identify potential targets for ferroptosis modulation.
Conducted molecular docking and dynamics simulations to investigate interactions within the SLC7A11/GPX4 pathway.
Focused on AKR1C1 as a potential upstream target for therapeutic intervention.
Identified AKR1C1 as a key target influencing ferroptosis regulation.
Demonstrated that lignans and stilbenes can act on the SLC7A11/GPX4 pathway.
Provided a scientific basis for developing neuroprotective agents from SAC.

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Implication

Study discovers lignans and stilbenes modulating ferroptosis in neuroprotection, suggesting agricultural benefits.

Abstract

mRNA. Network pharmacology, molecular docking, and dynamics simulations revealed AKR1C1 as a potential upstream target modulating ferroptosis. This work provides a scientific basis for developing SAC into functional neuroprotective agents and supports its value-added utilization as an agricultural resource.

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Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a00205ec8f74e3340f9b349 https://doi.org/10.1021/acs.jafc.6c00397

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Discovery of Lignans and Stilbenes from the Seeds of Astragalus complanatus in Ferroptosis Regulation via Directly Acting on SLC7A11/GPX4 Pathway

Key Points

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Implication

Abstract

Discussion

Cite This Study

Discovery of Lignans and Stilbenes from the Seeds of Astragalus complanatus in Ferroptosis Regulation via Directly Acting on SLC7A11/GPX4 Pathway

Key Points

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Implication

Abstract

Discussion

Cite This Study

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