Discovery of Lignans and Stilbenes from the Seeds of Astragalus complanatus in Ferroptosis Regulation via Directly Acting on SLC7A11/GPX4 Pathway

Key Points

• The study aims to discover lignans and stilbenes from Astragalus complanatus and their role in regulating ferroptosis.
• Utilized network pharmacology to identify potential targets for ferroptosis modulation.
• Conducted molecular docking and dynamics simulations to investigate interactions within the SLC7A11/GPX4 pathway.
• Focused on AKR1C1 as a potential upstream target for therapeutic intervention.
• Identified AKR1C1 as a key target influencing ferroptosis regulation.
• Demonstrated that lignans and stilbenes can act on the SLC7A11/GPX4 pathway.
• Provided a scientific basis for developing neuroprotective agents from SAC.