Revealing the Fate of Isomeric Monounsaturated Fatty Acids in Enterococcus faecalis Membrane Lipids and Their Influence on Antimicrobial Susceptibility

Rebekah L. Casey; Annika L. Silverberg; Michael T. Marty; Kelly M. Hines

doi:10.1021/acsinfecdis.6c00092

May 8, 2026ACS Infectious DiseasesOpen Access

Revealing the Fate of Isomeric Monounsaturated Fatty Acids in Enterococcus faecalis Membrane Lipids and Their Influence on Antimicrobial Susceptibility

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Key Points

This research aims to understand how different isomeric monounsaturated fatty acids affect the membrane lipid composition and antimicrobial susceptibility of Enterococcus faecalis strains.
Examined strains with genetic determinants for daptomycin resistance and those acquiring tolerance through fatty acid uptake.
Analyzed changes in membrane lipid composition and growth responses to biologically relevant fatty acid isomers.
Strains with genetic determinants for daptomycin resistance showed altered membrane lipid composition compared to tolerant strains.
Differences in overall growth responses to isomeric fatty acids were observed across different strains.

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Implication

Reveals differences in membrane lipid composition and growth in Enterococcus faecalis strains influenced by isomeric fatty acids, indicating implications for antimicrobial...

Abstract

strains with genetic determinants for daptomycin resistance respond differently, in membrane lipid composition and overall growth, to biologically relevant FA 18:1 isomers compared to strains that acquire daptomycin tolerance solely through exogenous fatty acid uptake.

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Casey et al. (2026) studied this question.

synapsesocial.com/papers/6a0020aec8f74e3340f9b781 https://doi.org/10.1021/acsinfecdis.6c00092

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Revealing the Fate of Isomeric Monounsaturated Fatty Acids in Enterococcus faecalis Membrane Lipids and Their Influence on Antimicrobial Susceptibility

Key Points

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Implication

Abstract

Discussion

Cite This Study

Revealing the Fate of Isomeric Monounsaturated Fatty Acids in Enterococcus faecalis Membrane Lipids and Their Influence on Antimicrobial Susceptibility

Key Points

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Implication

Abstract

Discussion

Cite This Study

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