What question did this study set out to answer?

The study aims to verify how a specific genetic change in the frizzled gene affects sleep duration and states in Drosophila.

May 10, 2026SLEEP

0049 Single Base Pair Change in Frizzled Affects Sleep State in Drosophila

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Randomized trial examines the impact of a frizzled gene polymorphism on sleep duration in Drosophila, indicating a genetic influence on sleep states.

The study aims to verify how a specific genetic change in the frizzled gene affects sleep duration and states in Drosophila.
Used a long-sleeping line from the Sleep Inbred Panel as the genetic background.
Replaced the 'G' allele with the 'T' allele using CRISPR/Cas9 to create modified lines.
Measured sleep duration with Trikinetics Drosophila Activity Monitors.
Decreased night sleep duration by 7.2 minutes (P = 0.0349) in one transformant line.
Decreased night sleep duration by 7.9 minutes (P = 0.0116) in another transformant line.
Flies with the 'G' allele spent significantly more time in deeper sleep states compared to those with the 'T' allele.

Lyman et al. (2026) studied this question.

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Randomized trial examines the impact of a frizzled gene polymorphism on sleep duration in Drosophila, indicating a genetic influence on sleep states.