What question did this study set out to answer?

This study aims to assess the effectiveness and satisfaction of low-sodium oxybate among adults with narcolepsy.

May 10, 2026SLEEP

1009 Effectiveness and Satisfaction with Low-Sodium Oxybate as Described by Adults Living with Narcolepsy: LYRICAL Survey & Interview Findings

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Mixed methods study examines treatment satisfaction and effectiveness of low-sodium oxybate in adults with narcolepsy, indicating promising results.

This study aims to assess the effectiveness and satisfaction of low-sodium oxybate among adults with narcolepsy.
Participants (N=59) completed online surveys at three timepoints: enrollment, week 12, and week 24.
Surveys included standardized measures like PGIC, PGIS, and TSQM-9.
A subset of participants completed qualitative interviews at enrollment and week 24.
93% of participants reported improvements in overall narcolepsy symptoms after starting low-sodium oxybate.
91.2% experienced improvement in excessive daytime sleepiness, with a mean TSQM-9 score of 74.3.
Over 90% noted improved quality of life, such as enhanced ability to drive, exercise, and socialize.

Drachenberg et al. (2026) studied this question.

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Mixed methods study examines treatment satisfaction and effectiveness of low-sodium oxybate in adults with narcolepsy, indicating promising results.