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May 10, 2026SLEEP

1010 Effectiveness and Satisfaction with Low-Sodium Oxybate as Described by Adults Living with Idiopathic Hypersomnia: LYRICAL Survey & Interview Findings

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Authors

CDC. DrachenbergMFMeagan FarrellJDJennifer D’Souza

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Overview

Longitudinal mixed methods study assesses treatment satisfaction and symptom improvement in adults with idiopathic hypersomnia, indicating positive experiences with low-sodium oxybate.

Key Points

  • The aim is to examine the real-world effectiveness and satisfaction with low-sodium oxybate in adults with idiopathic hypersomnia.
  • Participants taking low-sodium oxybate for at least 12 weeks completed online surveys and qualitative interviews.
  • Standardized patient-reported outcome measures were used to assess treatment experiences and symptom changes.
  • Data were collected at three timepoints: enrollment, week 12, and week 24.
  • 89.5% of participants reported improvements in overall idiopathic hypersomnia symptoms post-treatment.
  • High global treatment satisfaction mean TSQM-9 score was 70.0, with 76.9% reporting satisfaction.
  • 89.7% reported improved quality of life, and all interviewees expressed satisfaction with their treatment experience.

Cite This Study

Drachenberg et al. (2026) studied this question.

synapsesocial.com/papers/6a0021e6c8f74e3340f9ce3ahttps://doi.org/10.1093/sleep/zsag091.1009
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