What question did this study set out to answer?

This trial aims to evaluate the effectiveness of the clip-on-staple method in reducing clinically relevant postoperative pancreatic fistula after distal pancreatectomy.

May 10, 2026Annals of Surgery OpenOpen Access

A Multicenter, Single-Blind, Randomized Trial Comparing Stapler Closure With Clip-on-Staple Method Versus Stapler Closure Alone During Distal Pancreatectomy (CLIP-DP Trial)

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Authors

MNMizuki NinomiyaAso Iizuka Hospital KSKen ShirabeGunma University KFKengo FukuzawaOita Red Cross Hospital

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Implication

Randomized trial finds clip-on-staple method reduces postoperative fistulas in patients undergoing distal pancreatectomy, suggesting enhanced surgical technique.

Key Points

This trial aims to evaluate the effectiveness of the clip-on-staple method in reducing clinically relevant postoperative pancreatic fistula after distal pancreatectomy.
Multicenter, single-blind, randomized controlled trial across 16 Japanese institutions.
Patients undergoing distal pancreatectomy were randomized 1:1 to either stapler closure alone or the clip-on-staple method.
Primary endpoint was clinically relevant postoperative pancreatic fistula or death within 30 days.
In the full-analysis set, clinically relevant postoperative pancreatic fistula or death occurred in 23.5% of stapler closure alone versus 15.2% of clip-on-staple (P = 0.184).
In the per-protocol set, rates were 24.4% for stapler closure alone and 12.5% for clip-on-staple (P = 0.049).
Among patients with pancreatic thickness >12 mm, the clip-on-staple method significantly reduced rates of CR-POPF (FAS: 32.4% vs 11.9%, P = 0.032).

Cite This Study

Ninomiya et al. (2026) studied this question.

synapsesocial.com/papers/6a00217ac8f74e3340f9c56a https://doi.org/10.1097/as9.0000000000000666

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Implication

Randomized trial finds clip-on-staple method reduces postoperative fistulas in patients undergoing distal pancreatectomy, suggesting enhanced surgical technique.

A Multicenter, Single-Blind, Randomized Trial Comparing Stapler Closure With Clip-on-Staple Method Versus Stapler Closure Alone During Distal Pancreatectomy (CLIP-DP Trial)

Discussion

Member takes

Implication

Key Points

Cite This Study

A Multicenter, Single-Blind, Randomized Trial Comparing Stapler Closure With Clip-on-Staple Method Versus Stapler Closure Alone During Distal Pancreatectomy (CLIP-DP Trial)

Discussion

Member takes

Implication

Key Points

Cite This Study

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