Synthesis of azido-modified enamides via C=C isomerisation of functionalised Ugi adducts

Vladyslav O. Vereshchak; Sofia  M. Fadieieva; Yevhen  V. Kasianenko; Viacheslav E Saraiev; Olena  H. Shvets; Владимир И. Мусатов; Svitlana V. Shishkina; Valentyn A. Chebanov; A.V. Tsygankov

doi:10.1039/d6ob00513f

January 1, 2025Organic & Biomolecular Chemistry

Synthesis of azido-modified enamides via C=C isomerisation of functionalised Ugi adducts

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Key Points

This work aims to develop a new method for synthesizing azido-modified enamides using C=C isomerization.
Utilized multicomponent reactions to assemble building blocks.
Applied Ugi reaction for functionalization of adducts.
Implemented C=C isomerisation for the modification process.
Successfully synthesized azido-modified enamides with high yields.
The method demonstrated notable improvements in molecular diversity.
C=C isomerization effectively converted functionalized Ugi adducts.

Implication

Demonstrates effective synthesis of azido-modified enamides, suggesting advancements in organic chemistry.

Abstract

Multicomponent reactions (MCRs) represent a cornerstone of modern organic synthesis, offering rapid access to molecular diversity through the convergent assembly of building blocks. Among these, the Ugi reaction and its...

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Cite This Study

Vereshchak et al. (2025) studied this question.

synapsesocial.com/papers/6a0021cdc8f74e3340f9cc86 https://doi.org/10.1039/d6ob00513f

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Synthesis of azido-modified enamides via C=C isomerisation of functionalised Ugi adducts

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of azido-modified enamides via C=C isomerisation of functionalised Ugi adducts

Key Points

Implication

Abstract

Discussion

Cite This Study

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