Synthesis of azido-modified enamides via C=C isomerisation of functionalised Ugi adducts

Key Points

• This work aims to develop a new method for synthesizing azido-modified enamides using C=C isomerization.
• Utilized multicomponent reactions to assemble building blocks.
• Applied Ugi reaction for functionalization of adducts.
• Implemented C=C isomerisation for the modification process.
• Successfully synthesized azido-modified enamides with high yields.
• The method demonstrated notable improvements in molecular diversity.
• C=C isomerization effectively converted functionalized Ugi adducts.