What question did this study set out to answer?

To measure the lifespan of human humoral immunity across diverse viral and nonreplicating antigens and determine whether peripheral memory B-cell frequency directly correlates with circulating antibody levels over time.

November 7, 2007New England Journal of MedicineOpen Access

Duration of Humoral Immunity to Common Viral and Vaccine Antigens

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Authors

IAIan J. AmannaNajít Technologies (United States)NCNichole E. CarlsonColorado School of Public Health MSMark K. SlifkaOregon National Primate Research Center

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Implication

Longitudinal study reveals lifelong antiviral antibodies but faster-waning bacterial immunity in humans, suggesting independent regulation of memory B cells and antibody-secreting plasma cells.

Key Points

To measure the lifespan of human humoral immunity across diverse viral and nonreplicating antigens and determine whether peripheral memory B-cell frequency directly correlates with circulating antibody levels over time.
Tracked serum antibody titers against six viral antigens (vaccinia, measles, mumps, rubella, varicella-zoster virus, Epstein-Barr virus) and two nonreplicating vaccine antigens (tetanus, diphtheria) in N=45 individuals followed longitudinally for up to 26 years.
Quantified circulating antigen-specific memory B cells using limiting-dilution analysis to assess correlation with serum antibody levels.
Antiviral antibody responses remained stable with estimated half-lives ranging from 50 years for varicella-zoster virus to greater than 200 years for measles and mumps.
Antibodies targeting nonreplicating bacterial antigens waned substantially faster, demonstrating estimated half-lives of 11 years for tetanus and 19 years for diphtheria.
Peripheral antigen-specific memory B-cell frequencies did not significantly correlate with serum antibody concentrations for five of the eight antigens evaluated.

Cite This Study

Amanna et al. (2007) studied this question.

synapsesocial.com/papers/6a002dae6018b8d0892dad67 https://doi.org/10.1056/nejmoa066092

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Implication

Longitudinal study reveals lifelong antiviral antibodies but faster-waning bacterial immunity in humans, suggesting independent regulation of memory B cells and antibody-secreting plasma cells.

Duration of Humoral Immunity to Common Viral and Vaccine Antigens

Discussion

Member takes

Implication

Key Points

Cite This Study

Duration of Humoral Immunity to Common Viral and Vaccine Antigens

Discussion

Member takes

Implication

Key Points

Cite This Study

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