Transition Metal-Catalyzed C—P Bond Activation

Transition metal-catalyzed C-P bond activation provides an ecomomical and high-efficient route for the synthesis of organic phosphine compounds, and has received increasing attention in recent years. Owing to high bond energy of C-P bond and strong coordinative ability of P atom, the activation of C-P bond has been a fomidable challenge. Relying on substrate-preactivation and various catalysts, great progress has been achieved. This review will give a summary of this field, and according to different mechanisms of C-P bond activation and strategies of substrate pre-activation, a detailed description on reaction type, development, characteristics and mechanism will be made.