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The incidence of inflammatory bowel disease (IBD), a collective term for Crohn’s disease (CD) and ulcerative colitis (UC), has been increasing over time and expanding to different regions around the world, indicating that IBD is a global disease. IBD is a polygenic disease thought to be triggered by environmental factors. IBD may represent dysregulated mucosal inflammation in response to gut microbiota. A Western or westernized lifestyle is thought to be a major driver of the growing incidence of IBD. Currently, however, the key environmental factor for IBD is unidentified.
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Chiba et al. (2019) studied this question.
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