Why the study?
The endogenous agonists and origin of brain renin-angiotensin system receptors remain unknown, prompting questions on independent brain angiotensin generation, kidney interactions, and mechanisms of centrally acting RAS agents.
How do centrally acting RAS blockers and Mas receptor agonists function in the brain, and does independent angiotensin generation occur there?
How do centrally acting RAS blockers and Mas receptor agonists function in the brain, and does independent angiotensin generation occur there?
The review highlights the potential neuroprotective role of Mas receptor agonists after stroke and discusses the mechanisms of the brain renin-angiotensin system.
Mas agonists may offer post-stroke neuroprotection; leaves open endogenous ligand identification and brain RAS origin.
PURPOSE OF REVIEW: ) receptors. RECENT FINDINGS: and Mas receptor agonists are reported to induce neuroprotection after stroke. The endogenous agonists of these receptors and their origin remain unknown. This review addresses the questions whether independent angiotensin generation truly occurs in the brain, what its relationship with the kidney is, and how centrally acting RAS blockers/agonists might work.
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Ren et al. (2019) studied this question.
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