What question did this study set out to answer?

Determine the prevalence of systolic dysfunction in patients with diastolic heart failure using echocardiography.

March 12, 2002Circulation

Progression of Systolic Abnormalities in Patients With “Isolated” Diastolic Heart Failure and Diastolic Dysfunction

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Why the study?

Does tissue Doppler imaging detect systolic abnormalities in patients diagnosed with isolated diastolic heart failure or diastolic dysfunction compared to normal controls?

Population

339 subjects, including 92 with systolic heart failure, 73 with diastolic heart failure, 68 with isolated…

Comparison

Echocardiography with tissue Doppler imaging vs Normal control subjects

Design

Cross-sectional

Authors

CYCheuk‐Man YuHeart Failure / Cardiomyopathy HLHong LinSun Yat-sen University HYHua YangHebei Medical University

Discussion

Member takes

Implication

Questions isolated diastolic heart failure diagnoses; leaves open whether tissue Doppler imaging should refine systolic assessment in practice.

Key Points

Determine the prevalence of systolic dysfunction in patients with diastolic heart failure using echocardiography.
Echocardiography with tissue Doppler imaging was performed in 339 subjects.
Subjects included those with systolic heart failure (EF<50%), diastolic heart failure (EF ≥50%), and isolated diastolic dysfunction.
Regional myocardial velocity curves were analyzed off-line using a specific model.
Significantly lower peak regional myocardial velocities observed in SHF, DHF, and DD compared to controls (all P ≤ 0.001).
Mean sustained systolic velocity (S(M)) showed a gradient: SHF < DHF < DD < controls.
A mean S(M) of 4.4 cm/s predicted systolic dysfunction in 92% of SHF, 52% of DHF, and 14% of DD.

Structured PICO

Does tissue Doppler imaging detect systolic abnormalities in patients diagnosed with isolated diastolic heart failure or diastolic dysfunction compared to normal controls?

Population

339 subjects, including 92 with systolic heart failure (SHF, EF<50%), 73 with diastolic heart failure (DHF, EF ≥ 50% with diastolic abnormalities), 68 with isolated diastolic dysfunction (DD), and 106 normal control subjects.

Intervention

Echocardiography with tissue Doppler imaging

Comparator

Normal control subjects

Outcome

Peak regional myocardial sustained systolic (S(M)) and early diastolic (E(M)) velocitiessurrogate

Tissue Doppler imaging reveals that systolic dysfunction commonly coexists in patients diagnosed with isolated diastolic heart failure, suggesting a spectrum of combined systolic and diastolic abnormalities.

Cite This Study

Yu et al. (2002) studied this question.

synapsesocial.com/papers/6a011ea369ee78cdf851df55 https://doi.org/10.1161/hc1002.105185

Topics

HFrEF treatment Heart failure

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Implication

Questions isolated diastolic heart failure diagnoses; leaves open whether tissue Doppler imaging should refine systolic assessment in practice.

Progression of Systolic Abnormalities in Patients With “Isolated” Diastolic Heart Failure and Diastolic Dysfunction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Progression of Systolic Abnormalities in Patients With “Isolated” Diastolic Heart Failure and Diastolic Dysfunction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider