What question did this study set out to answer?

To determine whether early life exposure to the 1959–1961 Chinese famine modifies the relationship between type 2 diabetes mellitus and cardiovascular disease in adulthood.

August 7, 2019Journal of Diabetes

Early life exposure to 1959‐1961 Chinese famine exacerbates association between diabetes and cardiovascular disease

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Authors

ZSZumin ShiQatar University LJLinong JiNanjing Normal University RCRonald C.W.Kunming University of Science and Technology

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Implication

Cohort study uncovers heightened cardiovascular risk from diabetes in famine-exposed adults, suggesting early nutritional deprivation compounds adult metabolic damage.

Key Points

To determine whether early life exposure to the 1959–1961 Chinese famine modifies the relationship between type 2 diabetes mellitus and cardiovascular disease in adulthood.
Analyzed data from N=4,247 adults born between 1954 and 1964 from the 2011 and 2015 China Health and Retirement Longitudinal Study (CHARLS).
Defined diabetes in 2011 by fasting blood glucose, HbA1c, or prior diagnosis, and identified cardiovascular disease in 2011 and 2015 from doctor diagnoses of cardiac events or stroke.
Diabetes in 2011 was cross-sectionally associated with higher cardiovascular disease risk in 2011 (OR 1.91, 95% CI 1.53–2.40, P < 0.001) after adjusting for age and sex.
Famine exposure in severely affected regions increased subsequent cardiovascular risk among diabetic individuals, with the highest risks observed in fetal-exposed (OR 4.31, 95% CI 2.07–8.97) and early childhood-exposed cohorts (OR 2.25, 95% CI 1.29–3.91) compared to unexposed individuals (OR 1.72, 95% CI 0.84–3.51).

Cite This Study

Shi et al. (2019) studied this question.

synapsesocial.com/papers/6a0137be6018b8d0892decdb https://doi.org/10.1111/1753-0407.12975

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Implication

Cohort study uncovers heightened cardiovascular risk from diabetes in famine-exposed adults, suggesting early nutritional deprivation compounds adult metabolic damage.

Early life exposure to 1959‐1961 Chinese famine exacerbates association between diabetes and cardiovascular disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Early life exposure to 1959‐1961 Chinese famine exacerbates association between diabetes and cardiovascular disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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