The selection of a semisolid base type (hydrophobic, hydrophilic or emulsion) has an essential influence on the skin and transdermal delivery of active substances. The cutaneous and percutaneous absorption may be influenced by interactions occurring between base components and skin on the one hand and interactions between base components and the active ingredient on the other hand. The present article discusses the utility of different types of semisolid bases as carriers of active substances and summarizes results of studies comparing delivery of active substances from different semisolid bases.
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Jankowski et al. (2017) studied this question.