What question did this study set out to answer?

To investigate the direct effects of human and viral interleukin-10 on the proliferation, viability, and antibody differentiation of activated human B lymphocytes.

March 1, 1992Proceedings of the National Academy of SciencesOpen Access

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

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Authors

FRF RoussetL'Oréal (France)EGElisabeth GarciaUniversité Paris-Sud TDThierry DefranceUniversité Claude Bernard Lyon 1

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Implication

Experimental study demonstrates that interleukin-10 stimulates proliferation and antibody production in activated human B cells, highlighting its central role in amplifying humoral immunity.

Key Points

To investigate the direct effects of human and viral interleukin-10 on the proliferation, viability, and antibody differentiation of activated human B lymphocytes.
Activated human B lymphocytes in vitro through either their surface antigen receptor or the CD40 antigen pathway.
Cultured activated cells with human IL-10, viral IL-10 (BCRF1), or IL-10 in combination with IL-4 to evaluate DNA synthesis, viable cell yields, and immunoglobulin secretion profiles.
Both human and viral IL-10 stimulated DNA replication in B cells activated via antigen receptors or CD40, with IL-4 providing additive effects that substantially increased viable cell counts.
IL-10 induced activated B lymphocytes to secrete high levels of IgG, IgA, and IgM, whereas combining IL-10 and IL-4 prompted the secretion of all four major immunoglobulin isotypes.

Cite This Study

Rousset et al. (1992) studied this question.

synapsesocial.com/papers/6a01601fe92f4a033c85688a https://doi.org/10.1073/pnas.89.5.1890

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Implication

Experimental study demonstrates that interleukin-10 stimulates proliferation and antibody production in activated human B cells, highlighting its central role in amplifying humoral immunity.

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

Discussion

Member takes

Implication

Key Points

Cite This Study

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

Discussion

Member takes

Implication

Key Points

Cite This Study

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