Key result
Healthy diet plus physical activity linked to ~51% lower odds of advanced CKM syndrome.
Why the study?
Does sufficient physical activity and high dietary quality associate with lower odds of advanced cardiovascular-kidney-metabolic syndrome in older adults?
Cross-Sectional (n=5,036)
Does sufficient physical activity and high dietary quality associate with lower odds of advanced cardiovascular-kidney-metabolic syndrome in older adults?
Answers are grounded in this paper and cite their sources.
Sufficient physical activity and high dietary quality are jointly associated with significantly lower odds of advanced cardiovascular-kidney-metabolic syndrome in older adults.
OBJECTIVE: To examine the independent and joint associations of physical activity (PA) and dietary quality (HEI-2020) with the presence of advanced cardiovascular-kidney-metabolic syndrome (CKM) in older U.S. adults. DESIGN: A cross-sectional study. SITE: The 2007-2020 National Health and Nutrition Examination Survey (NHANES). PARTICIPANTS: Five thousand thirty-six individuals aged ≥60 years (2051 with advanced CKM). MAIN MEASUREMENTS: PA was measured using MET-min/week, and dietary quality was assessed via the HEI-2020 score. Weighted logistic regression, restricted cubic spline (RCS) analysis, mediation, and stratified analyses. RESULTS: Sufficient PA (OR=0.66, 95% CI: 0.54-0.80) and HEI-2020 ≥60 (OR=0.82, 95% CI: 0.67-0.99) were independently associated with lower odds of advanced CKM, with the strongest association observed for the combination of both factors (OR=0.49, 95% CI: 0.38-0.64). RCS analysis revealed a nonlinear association between PA and advanced CKM, while HEI-2020 showed a linear inverse association. Mediation analysis indicated that BMI and HDL-C accounted for 15.7% and 23.1% of these associations, respectively. Stratified analyses suggested stronger associations among individuals aged ≥70 years, women, and widowed, divorced, or separated individuals. CONCLUSION: Physical activity and dietary quality were jointly associated with lower odds of advanced CKM in older adults, and these associations may involve metabolic and inflammatory pathways. Multidimensional lifestyle strategies may be beneficial for populations with a higher burden of CKM, although longitudinal studies are needed to clarify temporality.
No takes yet. Share an insight, caveat, or question.
Wu et al. (2026) conducted a cross-sectional in Advanced cardiovascular-kidney-metabolic syndrome (CKM) (n=5,036). Combination of sufficient physical activity and high dietary quality (HEI-2020 ≥60) vs. Lower physical activity and/or dietary quality was evaluated on Presence of advanced cardiovascular-kidney-metabolic syndrome (CKM) (OR 0.49, 95% CI 0.38-0.64). The combination of sufficient physical activity and high dietary quality was associated with lower odds of advanced cardiovascular-kidney-metabolic syndrome (OR 0.49; 95% CI 0.38-0.64).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: