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July 10, 2026HealthcareOpen Access

Joint Association of Functional Impairment and Depression with Advanced Cardiovascular–Kidney–Metabolic Syndrome: A Cross-Sectional and Cohort Study Using Two Large Datasets

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Authors

YZYaning ZhengRWRuifeng Wang

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Overview

Cross-sectional and cohort analysis reveals significant links between functional impairment, depression, and advanced CKM syndrome in older adults, indicating implications for screening.

Key Points

  • The study investigates how functional impairment and depression jointly affect advanced cardiovascular–kidney–metabolic syndrome in middle-aged and older individuals.
  • Performed cross-sectional analysis using the National Health and Nutrition Examination Survey (NHANES) in the U.S.
  • Conducted cohort analysis with the China Health and Retirement Longitudinal Study (CHARLS).
  • Employed multivariable logistic regression to analyze associations of functional impairment and depression with advanced CKM syndrome.
  • In NHANES, IADL/depression showed OR=4.843 (95% CI: 2.505, 9.366) and BADL/depression OR=4.394 (95% CI: 2.281, 8.464) for advanced CKM syndrome.
  • In CHARLS, IADL/depression OR=2.259 (95% CI: 1.517, 3.319) and BADL/depression OR=2.287 (95% CI: 1.501, 3.419) associated with advanced CKM syndrome.

Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/6a508da76eeac72a437a10c4https://doi.org/10.3390/healthcare14142043
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Association Between Depression and Advanced Stages of Cardiovascular–Kidney–Metabolic Syndrome2026
  2. 2Depression Symptoms and Advanced Cardiovascular–Kidney–Metabolic Syndrome in U.S. Adults: The Moderating Role of Sex2026
  3. 3Association between cardiovascular-kidney-metabolic syndromeand depressive symptoms in middle-aged and older Chineseadults: a cross-sectional and longitudinal analysis2026
  4. 4Association of cardiovascular-kidney-metabolic syndrome with depression and all-cause mortality: a population-based observational study2025 · 6 citations
  5. 5Depression and risk of incident heart diseases among older adults at CKM stages 0–3: evidence from the China Health and Retirement Longitudinal Study2026