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May 11, 2026iLiverOpen Access

Targeting Tumor-associated Macrophages in Pancreatic Cancer

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Authors

YLYuxi LongLXLuoyingzi XieFXFuming Xie

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Overview

Review summarizes current macrophage-targeted therapies in pancreatic cancer, indicating potential for improved outcomes.

Key Points

  • This review aims to summarize the understanding of tumor-associated macrophage polarization and therapeutic strategies in pancreatic cancer.
  • Conducted a comprehensive literature review on TAM biology and signaling pathways involved in polarization.
  • Analyzed preclinical therapeutic approaches and current clinical trial evidence regarding TAM-targeted therapies in PDAC.
  • Emphasized translational advances and clinical challenges in targeting TAMs.
  • M2-polarized TAMs correlate with poor prognosis in pancreatic cancer, suggesting their role in immunosuppression.
  • Interventions targeting TAMs via CSF-1R inhibition and STAT3 blockade can promote anti-tumor immunity.
  • Emerging strategies, such as galectin-9/TIM-3 inhibition and SYK targeting, show promise in disrupting tumor-promoting interactions.

Cite This Study

Long et al. (2026) studied this question.

synapsesocial.com/papers/6a0171983a9f334c28271c9bhttps://doi.org/10.1016/j.iliver.2026.100243
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Also Consider

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  1. 1Progress in targeting tumor-associated macrophages in cancer immunotherapy2025 · 39 citations
  2. 2Strategies to Target the Tumor-Associated Macrophages in the Immunosuppressive Microenvironment of Pancreatic Ductal Adenocarcinoma2025
  3. 3Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments2025 · 309 citations
  4. 4Research advances on tumor-associated macrophages in pancreatic cancer2026
  5. 5The pivotal role of macrophages in tumorigenesis and pioneering cancer immunotherapy across pre-clinical and clinical frontiers2026