Demonstrates enantioselective coupling of aziridines with alkynyl bromides, implying a new synthetic pathway.
-amino acids. Mechanistic studies were indicative of the aziridine being activated through a regioselective nucleophilic halide ring opening and subsequent enantioselective XEC of the generated β-amino benzyl halides with alkynyl bromides.
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Lan et al. (2026) studied this question.
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