Enantio- and regioselective nickel/photoredox-catalyzed cross-electrophile coupling of benzylic aziridines with alkynyl bromides.

Key Points

• This research aims to explore a novel method for enantio- and regioselective coupling of aziridines with alkynyl bromides.
• Utilized nickel and photoredox catalysis for the reaction process.
• Investigated the mechanistic pathway, focusing on the nucleophilic halide ring opening.
• Analyzed the resulting β-amino benzyl halides for coupling efficiency.
• The reaction demonstrated high enantioselectivity with a notable yield of the desired products.
• Mechanistic studies confirmed the regioselective nature of the aziridine activation.
• Replication of the method showcased consistent results under the defined conditions.