Nickel-Catalyzed Reductive Cross-Coupling of Aziridines and Benzyl Chlorides

Jie Wan; Senlin Wang; Chuanfu Liu; Yu-Lu Chen; Hai‐Liang Ni; Peng Cao; Ping Hu; Bi‐Qin Wang; Bin Chen

doi:10.1039/d5ob01299f

January 1, 2025Organic & Biomolecular Chemistry

Nickel-Catalyzed Reductive Cross-Coupling of Aziridines and Benzyl Chlorides

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Key Points

This method markedly enables the synthesis of β-benzyl-substituted arylethylamines, enhancing availability.
The reaction demonstrates effective coupling using manganese metal as a reducing agent, yielding higher efficiency.
This approach employs a nickel-catalyzed reductive cross-coupling strategy to facilitate complex molecule assembly.
The synthetic protocol provides reliable access to valuable compounds, suggesting versatility in chemical synthesis applications.

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Implication

Nickel-catalyzed method improves synthesis of β-benzyl-substituted arylethylamines from aziridines and benzyl chlorides, highlighting efficiency.

Abstract

A nickel-catalyzed reductive cross-coupling of aziridines and benzyl chlorides was realized by using manganese metal as the reducing agent. This protocol afforded a convenient approach to obtain β-benzyl-substituted arylethylamines bearing...

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Wan et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f710 https://doi.org/10.1039/d5ob01299f

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Nickel-Catalyzed Reductive Cross-Coupling of Aziridines and Benzyl Chlorides

Key Points

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Implication

Abstract

Discussion

Cite This Study

Nickel-Catalyzed Reductive Cross-Coupling of Aziridines and Benzyl Chlorides

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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