In Ni-catalyzed reactions, regioselective hydroalkenylation produces homoallylic amines from alkynes and aziridines, indicating broad substrate versatility.
Herein, we describe a Ni-catalyzed regioselective hydroalkenylation of alkynes with aziridines as coupling partners. This protocol allows access to homoallylic amines without recourse to stoichiometric amounts of well-defined organometallic reagents via catalytic regioselective ring-opening of aziridines under mild reaction conditions. The protocol is characterized by its applicability across a wide variety of aziridines or alkynes, including challenging substrate combinations.
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Zimin et al. (2025) studied this question.
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