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May 11, 2026Transactions of the Royal Society of Tropical Medicine and Hygiene

Antibody response following rabies vaccination: a retrospective cohort study from a tertiary centre in Kerala, India

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Authors

RSRahul SureshGovernment Medical CollegeCSChintha SujathaGovernment Medical CollegeASAmala Panackal SajuGovernment Medical College

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Implication

Retrospective cohort study assesses antibody persistence and optimal booster timing following rabies vaccination.

Key Points

  • The study evaluates the antibody response and long-term persistence post-rabies vaccination, including predictors for booster timing.
  • Retrospective cohort study of 150 participants at Government Medical College, Thiruvananthapuram.
  • Anti-rabies antibody titer measured using the Rapid Fluorescent Foci Inhibition Test.
  • Receiver operating characteristic (ROC) curve analysis conducted to determine optimal booster timing.
  • 92.7% of participants achieved protective antibody titers (≥0.5 IU/ml) with a mean titer of 3.81 IU/ml.
  • ROC analysis suggested five years as the optimal cut-off for booster doses.
  • Regression analysis indicated recent vaccination (P = .003) and intramuscular route (P = .005) as significant predictors of high antibody titers.

Cite This Study

Suresh et al. (2026) studied this question.

synapsesocial.com/papers/6a01720a3a9f334c28272286https://doi.org/10.1093/trstmh/trag055
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  1. 1Factors influencing delay in initiating post-exposure prophylaxis for rabies prevention among animal bite victims: A cross sectional study2020 · 22 citations
  2. 2Failure of Multiple‐Site Intradermal Postexposure Rabies Vaccination in Patients with Human Immunodeficiency Virus with Low CD4+T Lymphocyte Counts2001 · 69 citations
  3. 3Antibody Response Following Pre-Exposure Immunization Against Rabies in High-Risk Professionals2019 · 6 citations