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August 7, 2026Tropical Diseases Travel Medicine and VaccinesOpen Access

Rabies viral RNA and antibody response after post-exposure prophylaxis: Implications for blood donor deferral

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Authors

ASAman Dev SinghSOSimmi OberoiKSKanwardeep Singh

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Overview

Randomized trial assesses rabies response in adults post-exposure, suggesting policy revision for blood donation.

Key Points

  • Assess rabies viral RNA and antibody responses post-PEP to evaluate blood donor deferral policies.
  • Single-center interventional study in North India with 20 participants
  • Participants received anti-rabies vaccines and immunoglobulin post-bite
  • Samples tested for rabies RNA and antibody titers at 48-120 days post-exposure.
  • All participants tested negative for rabies viral RNA via RT-PCR.
  • ELISA antibody titers ranged from 0.881 to 4.449 IU/mL with a mean of 2.97 ± 1.04 IU/mL, exceeding 0.5 IU/mL.
  • Findings indicate effective PEP response, supporting reconsideration of one-year deferral policy.

Cite This Study

Singh et al. (2026) studied this question.

synapsesocial.com/papers/6a758bef847ab6d26c01f8fehttps://doi.org/10.1186/s40794-026-00312-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Paws to Pause: Trends in blood donor deferral rates due antirabies vaccination following animal bite: A 4-year retrospective study from a tertiary care hospital blood center in Delhi2026 · 1 citations
  2. 2IJCM_280A: A prospective study on safety and clinical efficacy of rabies biologicals in paediatric patients with category III animal exposure2024
  3. 3Antibody response following rabies vaccination: a retrospective cohort study from a tertiary centre in Kerala, India2026 · 1 citations
  4. 4Factors influencing rabies vaccines immunogenicity during post-exposure prophylaxis: a systematic literature search and meta-analysis2026
  5. 5Circulating Antibody’s Role During Post-Exposure Prophylaxis, and Beyond for Rabies: A Review2025