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July 21, 2025VaccinesOpen Access

Circulating Antibody’s Role During Post-Exposure Prophylaxis, and Beyond for Rabies: A Review

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Authors

QCQingjun ChenLCLi CaiXLXinjun Lv

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Overview

This review highlights PEP failure factors in rabies and underscores the importance of circulating antibodies in prevention efforts, indicating a critical social involvement.

Key Points

  • Rabies prophylaxis has been widely used since 1885 but has seen 124 documented PEP failures between 1980 and 2023.
  • Successful PEP requires adherence to practices like wound cleansing, immunoglobulin administration, and vaccination.
  • High-concentration circulating antibodies are vital, especially for high-risk people, to minimize PEP failures.
  • Societal involvement is essential to address rabies effectively and achieve WHO's 'zero by 30' goal.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd50chttps://doi.org/10.3390/vaccines13070775
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rabies Despite Post-Exposure Prophylaxis in High-Burden Settings: Vaccine Failure or Gaps in Healthcare Delivery?2025 · 2 citations
  2. 2The Critical Need for a Comprehensive Post-Exposure Care Bundle following Rabies Exposure: A Report of Two Cases2026
  3. 3Factors influencing rabies vaccines immunogenicity during post-exposure prophylaxis: a systematic literature search and meta-analysis2026
  4. 4Rabies viral RNA and antibody response after post-exposure prophylaxis: Implications for blood donor deferral2026
  5. 5Rabies Encephalitis following Post Exposure prophylaxis (PEP) is becoming an evolving problem in Bangladesh.2024 · 3 citations